Manuel Kukuljan

Médico Cirujano, Universidad de Valparaíso, 1986; Doctor en Ciencias Biomédicas, Universidad de Chile, 1994; Fogarty Visiting Fellow y Fogarty Visiting Associate, National Institutes of Health, Bethesda, E.E.U.U de A., 1988-1993. Pew Latinamerican Fellow, 1991-1993.

Profesor Asociado, Director, Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile.

Mi interés actual es comprender los mecanismos de diferenciación neuronal, y en particular los que subyacen al desarrollo y regulación de la excitabilidad.

Teléono: (56-2) 978 6707- (56-2) 678 6047
e-mail: kukuljan@neuro.med.uchile.cl

 
Developmental regulation of the expression of sodium currents in Xenopus primary neurons. Patricio Olguin, Ricardo Armisen and Manuel Kukuljan. Biol. Res., en prensa, 2006.
RE-1 Silencer of Transcription/Neural Restrictive Silencer Factor Modulates Ectodermal Patterning during Xenopus Development. Patricio Olguin, Pablo Oteiza, Eduardo Gamboa, Jose Luis Gomez-Skarmeta, and Manuel Kukuljan. J. Neurosci. 2006;26 2820-2829.
Kukuljan M, Taylor A, Chouinard H, Olguín P, Rojas CV, Ribera AB. Selective regulation of xSlo splice variants during Xenopus embryogenesis. J Neurophysiol. 2003 90:3352-60.
Armisén R, Fuentes R, Olguín P, Cabrejos ME, Kukuljan M. Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus. J Neurosci. 2002, 22:8347-51.
Palma V, Kukuljan M, Mayor R. Calcium mediates dorsoventral patterning of mesoderm in Xenopus. Curr Biol. 2001,11:1606-10.
Rojas CV, Neely A, Velasco-Loyden G, Palma V, Kukuljan M. Hyperkalemic periodic paralysis M1592V mutation modifies activation in human skeletal muscle Na+ channel. Am J Physiol. 1999, 276:C259-66.
Kukuljan M, Labarca P, Latorre R. Molecular determinants of ion conduction and inactivation in K+ channels. Am J Physiol. 1995 268:C535-56. Review.